JNJ7777120

Catalog No. A12713

JNJ7777120是有效的，选择性的非咪唑histamine H4 receptor拮抗剂。

Product Citations

K Yamamoto, .et al. Activation of orexinergic and histaminergic pathway involved in therapeutic effect of histamine H4 receptor antagonist against cisplatin-induced anorexia in mice, Naunyn-Schmiedeberg's Arch Pharmacol, 2019, pp 1-12
Yamamoto K, .et al. Effects of a histamine H4 receptor antagonist on cisplatin-induced anorexia in mice, Neurosci Lett, 2018, May 29;676:103-107 PMID: 29655943

Technical details

Catalog Num	A12713
M. Wt	277.75
Formula	C14H16N3OCl
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	459168-41-3
Synonyms	JNJ 7777120, JNJ-7777120
SMILES	CN1CCN(CC1)C(=O)C2=CC3=C(N2)C=CC(=C3)Cl

Biological Activity

JNJ7777120是有效的，选择性的非咪唑histamine H4 receptor拮抗剂。

Solubility *

In vitro (25°C)	DMSO	49 mg/mL (176.42 mM)
	Water	Insoluble
	Ethanol	7 mg/mL (25.2 mM)
In vivo	30% propylene glycol, 5% Tween 80, 65% D5W	19 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	36 mL	180.02 mL	360.04 mL
0.5 mM	7.2 mL	36 mL	72.01 mL
1 mM	3.6 mL	18 mL	36 mL
5 mM	0.72 mL	3.6 mL	7.2 mL

*The above data is based on the productmolecular weight 277.75. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.