TIC10 isomer

Catalog No. A12720

TIC10通过Foxo3a使Akt和ERK失活，从而诱导TRAIL，具有优越的药物特性：跨血脑屏障传递，优异的稳定性和改善的药代动力学。

Technical details

Catalog Num	A12720
M. Wt	386.5
Formula	C24H26N4O
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	41276-02-2
Synonyms	TIC 10, TIC-10
SMILES	CC1=CC=CC=C1CN2C3=C(CN(CC3)CC4=CC=CC=C4)C(=O)N5C2=NCC5

Biological Activity

TIC10通过Foxo3a使Akt和ERK失活，从而诱导TRAIL，具有优越的药物特性：跨血脑屏障传递，优异的稳定性和改善的药代动力学。

Targets

Akt	ERK

Solubility *

In vitro	DMSO	11 mg/mL (28.46 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	25.87 mL	129.37 mL	258.73 mL
0.5 mM	5.17 mL	25.87 mL	51.75 mL
1 mM	2.59 mL	12.94 mL	25.87 mL
5 mM	0.52 mL	2.59 mL	5.17 mL

*The above data is based on the productmolecular weight 386.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.