Dynasore

Catalog No. A12726

dynasore是一种非竞争性的dynamin 1，dynamin 2和线粒体dynamin（Drp1）GTPase活性抑制剂。

Product Citations

KOLAC UK, .et al. Chemical Inhibition of Mitochondrial Fission Improves Mitochondrial Function and Subdues Hyperglycemia Induced Stress in Placental Trophoblast Cells, Research Square, 2022, 03 Jun
Tsukamoto H, .et al. Lipopolysaccharide (LPS)-binding protein stimulates CD14-dependent Toll-like receptor 4 internalization and LPS-induced TBK1-IKKε-IRF3 axis activation, J Biol Chem, 2018, Jun 29;293(26):10186-10201 PMID: 29760187
Shigetoshi Yokoyama, .et al. A novel pathway of LPS uptake through syndecan-1 leading to pyroptotic cell death, eLife, 2018, 7: e37854 PMID: 30526845
Naoko Fujii, .et al. Hypotonic Stress-induced Down-regulation of Claudin-1 and -2 Mediated by Dephosphorylation and Clathrin-dependent Endocytosis in Renal Tubular Epithelial Cells, J Biol Chem, 2016, Nov 18; 291(47): 24787-24799 PMID: 27733684

Technical details

Catalog Num	A12726
M. Wt	322.32
Formula	C18H14N2O4
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	304448-55-3
Synonyms
SMILES	C1=CC=C2C=C(C(=CC2=C1)C(=O)NN/C=C/3\C=CC(=O)C(=C3)O)O

Biological Activity

dynasore是一种非竞争性的dynamin 1，dynamin 2和线粒体dynamin（Drp1）GTPase活性抑制剂。

Targets

Dynamin1/2 (Cell-free assay)
~15 μM

Solubility *

In vitro (25°C)	DMSO	60 mg/mL (186.15 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	5% DMSO+30% PEG 300+5% Tween 80+ddH2O	3 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	31.03 mL	155.13 mL	310.25 mL
0.5 mM	6.21 mL	31.03 mL	62.05 mL
1 mM	3.1 mL	15.51 mL	31.03 mL
5 mM	0.62 mL	3.1 mL	6.21 mL

*The above data is based on the productmolecular weight 322.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.