Stattic

Catalog No. A12733

Stattic是第一个非肽类STAT3小分子抑制剂，有效抑制STAT3激活和核易位，IC50为5.1 μM，可通过阻断磷酸化和二聚化事件来选择性抑制Stat3转录因子的激活。

Technical details

Catalog Num	A12733
M. Wt	211.19
Formula	C8H5NO4S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	19983-44-9
Synonyms	STAT3 Inhibitor V
SMILES	C1=CC(=CC2=C1C=CS2(=O)=O)[N+](=O)[O-]

Biological Activity

Stattic是第一个非肽类STAT3小分子抑制剂，有效抑制STAT3激活和核易位，IC50为5.1 μM，可通过阻断磷酸化和二聚化事件来选择性抑制Stat3转录因子的激活。

Targets

STAT3 (Cell-free assay)
5.1 μM

Solubility *

In vitro (25°C)	DMSO	38 mg/mL (179.93 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	5% DMSO+40% PEG 300+5% Tween 80+50% ddH2O	9 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	47.35 mL	236.75 mL	473.51 mL
0.5 mM	9.47 mL	47.35 mL	94.7 mL
1 mM	4.74 mL	23.68 mL	47.35 mL
5 mM	0.95 mL	4.74 mL	9.47 mL

*The above data is based on the productmolecular weight 211.19. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.