EPZ-5676 (Pinometostat)

Catalog No. A12735

EPZ-5676 (Pinometostat)是组蛋白甲基转移酶的小分子抑制剂，具有潜在的抗肿瘤活性。

Product Citations

Yoo H, .et al. Epigenetic priming by Dot1l in lymphatic endothelial progenitors ensures normal lymphatic development and function, Cell Death Dis, 2020, Jan; 11(1): 14 PMID: 31908356
Guang Bai, .et al. Chapter 1 - Epigenetic Tools in Chronic Pain Studies, Epigenetics of Chronic Pain, 2019, Pages 1-48

Technical details

Catalog Num	A12735
M. Wt	562.7
Formula	C30H42N8O3
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1380288-87-8
Synonyms	EPZ5676, EPZ 5676
SMILES	CC(C)N(C[C@@H]1[C@H]([C@H]([C@@H](O1)N2C=NC3=C2N=CN=C3N)O)O)C4CC(C4)CCC5=NC6=C(N5)C=C(C=C6)C(C)(C)C

Biological Activity

EPZ-5676 (Pinometostat)是组蛋白甲基转移酶的小分子抑制剂，具有潜在的抗肿瘤活性。

Targets

DOT1L (Cell-free assay)
80 pM(Ki)

Solubility *

In vitro (25°C)	DMSO	Warmed: 88 mg/mL (156.38 mM)
	Water	Insoluble
	Ethanol	Warmed: 81 mg/mL (143.94 mM)
In vivo	2% DMSO+30% PEG 300+5% Tween 80+ddH2O	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	17.77 mL	88.86 mL	177.71 mL
0.5 mM	3.55 mL	17.77 mL	35.54 mL
1 mM	1.78 mL	8.89 mL	17.77 mL
5 mM	0.36 mL	1.78 mL	3.55 mL

*The above data is based on the productmolecular weight 562.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.