IWR-1-endo

Catalog No. A12737

IWR-1-endo是Wnt应答的有效抑制剂，可阻断基于细胞的Wnt /β-catenin途径报道分子应答，IC50值为180 nM。 Wnt蛋白与细胞表面的受体结合，启动信号级联反应，从而导致β-catenin激活基因转录。

Product Citations

Charles A.Herring, .et al. Human prefrontal cortex gene regulatory dynamics from gestation to adulthood at single-cell resolution, Cell, 2022, Oct 27;S0092-8674(22)01258-2 PMID: 36318921

Technical details

Catalog Num	A12737
M. Wt	409.44
Formula	C25H19N3O3
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1127442-82-3
Synonyms
SMILES	C1C2C=CC1C3C2C(=O)N(C3=O)C4=CC=C(C=C4)C(=O)NC5=CC=CC6=C5N=CC=C6

Biological Activity

Targets

Wnt (L-cells expressing Wnt3A)
180 nM

Solubility *

In vitro	DMSO	19 mg/mL (46.4 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	24.42 mL	122.12 mL	244.24 mL
0.5 mM	4.88 mL	24.42 mL	48.85 mL
1 mM	2.44 mL	12.21 mL	24.42 mL
5 mM	0.49 mL	2.44 mL	4.88 mL

*The above data is based on the productmolecular weight 409.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.