EHop-016

Catalog No. A12740

EHop-016 is a potent and specific inhibitor of Rac1 and Rac3 GTPase activity that inhibits Vav2 interaction with Rac, Rac-activated PAK1, lamellipodia formation, and cell migration.

Technical details

Catalog Num	A12740
M. Wt	430.55
Formula	C25H30N6O
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1380432-32-5
Synonyms	EHop016
SMILES	CCN1C2=C(C=C(C=C2)NC3=NC(=NC=C3)NCCCN4CCOCC4)C5=CC=CC=C51

Biological Activity

EHop-016 is a potent and specific inhibitor of Rac1 and Rac3 GTPase activity that inhibits Vav2 interaction with Rac, Rac-activated PAK1, lamellipodia formation, and cell migration.

Targets

Rac1 (MDA-MB-435, MDA-MB-231 cells)
1.1 μM

Solubility *

In vitro (25°C)	DMSO	83 mg/mL (192.77 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	2% DMSO+30% PEG 300+5% Tween 80+ddH2O	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	23.23 mL	116.13 mL	232.26 mL
0.5 mM	4.65 mL	23.23 mL	46.45 mL
1 mM	2.32 mL	11.61 mL	23.23 mL
5 mM	0.46 mL	2.32 mL	4.65 mL

*The above data is based on the productmolecular weight 430.55. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.