QNZ (EVP4593)

Catalog No. A12748

QNZ抑制转录因子NF-κB的激活，已被用于研究NF-κB信号传导。

Technical details

Catalog Num	A12748
M. Wt	356.4
Formula	C22H20N4O
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	545380-34-5
Synonyms	CAY10470, CAY 10470, CAY-10470
SMILES	C1=CC=C(C=C1)OC2=CC=C(C=C2)CCNC3=NC=NC4=C3C=C(C=C4)N

Biological Activity

QNZ抑制转录因子NF-κB的激活，已被用于研究NF-κB信号传导。

Targets

TNF-α (Jurkat T cells)	NF-κB (Jurkat T cells)
7 nM	11 nM

Solubility *

In vitro (25°C)	DMSO	Warmed: 5 mg/mL (14.02 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	0.5% hydroxyethyl cellulose	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	28.06 mL	140.29 mL	280.58 mL
0.5 mM	5.61 mL	28.06 mL	56.12 mL
1 mM	2.81 mL	14.03 mL	28.06 mL
5 mM	0.56 mL	2.81 mL	5.61 mL

*The above data is based on the productmolecular weight 356.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.