UPF 1069

Catalog No. A12750

UPF 1069是一种选择性聚（ADP-核糖）聚合酶（PARP）2抑制剂（PARP-2和PARP-1的IC50值分别为0.3和8.0μM）。

Technical details

Catalog Num	A12750
M. Wt	279.29
Formula	C17H13NO3
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1048371-03-4
Synonyms	UPF1069, UPF-1069
SMILES	C1=CC=C(C=C1)C(=O)COC2=CC=CC3=C2C=CNC3=O

Biological Activity

UPF 1069是一种选择性聚（ADP-核糖）聚合酶（PARP）2抑制剂（PARP-2和PARP-1的IC50值分别为0.3和8.0μM）。

Targets

PARP2	PARP1
0.3 μM	8.0 μM

Solubility *

In vitro (25°C)	DMSO	54 mg/mL (193.34 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	2% DMSO+30% PEG 300+5% Tween 80+ddH2O	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	35.81 mL	179.03 mL	358.05 mL
0.5 mM	7.16 mL	35.81 mL	71.61 mL
1 mM	3.58 mL	17.9 mL	35.81 mL
5 mM	0.72 mL	3.58 mL	7.16 mL

*The above data is based on the productmolecular weight 279.29. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.