NU7026

Catalog No. A12752

NU7026是一种新型的在无细胞试验中IC50为0.23 μM，作用于DNA-PK比作用于PI3K选择性高60倍，对ATM和ATR没有抑制活性。可增强用于治疗白血病的拓扑异构酶II毒物的细胞毒性。

Product Citations

Velichko AK, .et al. Hypoosmotic stress induces R loop formation in nucleoli and ATR/ATM-dependent silencing of nucleolar transcription, Nucleic Acids Res, 2019, May 22. pii: gkz436 PMID: 31114877

Technical details

Catalog Num	A12752
M. Wt	281.31
Formula	C17H15NO3
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	154447-35-5
Synonyms	NU 7026, NU-7026
SMILES	C1COCCN1C2=CC(=O)C3=C(O2)C4=CC=CC=C4C=C3

Biological Activity

Targets

DNA-PK (Cell-free assay)	PI3K (Cell-free assay)	ATM (Cell-free assay)	ATR (Cell-free assay)
0.23 μM	13 μM	>100 μM	>100 μM

Solubility *

In vitro (25°C)	DMSO	1 mg/mL (3.55 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	1% DMSO+30% polyethylene glycol+1% Tween 80	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	35.55 mL	177.74 mL	355.48 mL
0.5 mM	7.11 mL	35.55 mL	71.1 mL
1 mM	3.55 mL	17.77 mL	35.55 mL
5 mM	0.71 mL	3.55 mL	7.11 mL

*The above data is based on the productmolecular weight 281.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.