LDE225 Diphosphate
Catalog No. A12774
LDE225 Diphosphate 是一种具有潜在抗肿瘤活性的口服生物利用小分子平滑（Smo）拮抗剂。抑制Hedgehog (Hh)信号通路，无细胞试验中IC50分别为1.3 nM (小鼠)和2.5 nM(人)。
| Catalog Num | A12774 |
|---|---|
| M. Wt | 681.49 |
| Formula | C26H32F3N3O11P2 |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 1218778-77-8 |
| Synonyms | LDE-225, LDE 225 |
| SMILES | C[C@@H]1CN(C[C@@H](O1)C)C2=NC=C(C=C2)NC(=O)C3=CC=CC(=C3C)C4=CC=C(C=C4)OC(F)(F)F.OP(=O)(O)O.OP(=O)(O)O |
LDE225 Diphosphate 是一种具有潜在抗肿瘤活性的口服生物利用小分子平滑（Smo）拮抗剂。抑制Hedgehog (Hh)信号通路，无细胞试验中IC50分别为1.3 nM (小鼠)和2.5 nM(人)。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 14.67 mL | 73.37 mL | 146.74 mL |
| 0.5 mM | 2.93 mL | 14.67 mL | 29.35 mL |
| 1 mM | 1.47 mL | 7.34 mL | 14.67 mL |
| 5 mM | 0.29 mL | 1.47 mL | 2.93 mL |
*The above data is based on the productmolecular weight 681.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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