Crisaborole (AN2728)

Catalog No. A12776

AN2728是一种局部给药的含硼抗炎化合物，可抑制PDE4活性，从而抑制TNFalpha，IL-12，IL-23和其他细胞因子的释放。抑制PDE4的 IC50 值为0.49 μM。

Technical details

Catalog Num	A12776
M. Wt	251.08
Formula	C14H10BNO3
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	906673-24-3
Synonyms	AN 2728, AN-2728
SMILES	B1(C2=C(CO1)C=C(C=C2)OC3=CC=C(C=C3)C#N)O

Biological Activity

AN2728是一种局部给药的含硼抗炎化合物，可抑制PDE4活性，从而抑制TNFalpha，IL-12，IL-23和其他细胞因子的释放。抑制PDE4的 IC50 值为0.49 μM。

Solubility *

In vitro	DMSO	47 mg/mL (187.21 mM)
	Water
	Ethanol
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	39.83 mL	199.14 mL	398.28 mL
0.5 mM	7.97 mL	39.83 mL	79.66 mL
1 mM	3.98 mL	19.91 mL	39.83 mL
5 mM	0.8 mL	3.98 mL	7.97 mL

*The above data is based on the productmolecular weight 251.08. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Adooq Bioscience

Crisaborole (AN2728)

Technical details

Biological Activity

Solubility *

Preparing Stock Solutions