Alvelestat

Catalog No. A12779

Avelestat，也称为AZD9668，是可口服的,高度选择性neutrophil elastase (NE)抑制剂，IC50和Ki分别为12 nM和9.4 nM,其选择性超过其他丝氨酸蛋白酶至少600倍。

Technical details

Catalog Num	A12779
M. Wt	545.5
Formula	C25H22F3N5O4S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	848141-11-7
Synonyms	AZD9668,AZD 9668,AZD-9668
SMILES	CC1=C(C=C(C(=O)N1C2=CC=CC(=C2)C(F)(F)F)C(=O)NCC3=NC=C(C=C3)S(=O)(=O)C)C4=CC=NN4C

Biological Activity

Avelestat，也称为AZD9668，是可口服的,高度选择性neutrophil elastase (NE)抑制剂，IC50和Ki分别为12 nM和9.4 nM,其选择性超过其他丝氨酸蛋白酶至少600倍。

Targets

neutrophil elastase	neutrophil elastase
9.4 nM(Ki)	12 nM

Solubility *

In vitro	DMSO	87 mg/mL (159.47 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	18.33 mL	91.66 mL	183.32 mL
0.5 mM	3.67 mL	18.33 mL	36.66 mL
1 mM	1.83 mL	9.17 mL	18.33 mL
5 mM	0.37 mL	1.83 mL	3.67 mL

*The above data is based on the productmolecular weight 545.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.