Alvelestat
Catalog No. A12779
Avelestat,也称为AZD9668,是可口服的,高度选择性neutrophil elastase (NE)抑制剂,IC50和Ki分别为12 nM和9.4 nM,其选择性超过其他丝氨酸蛋白酶至少600倍。
Catalog Num | A12779 |
---|---|
M. Wt | 545.5 |
Formula | C25H22F3N5O4S |
Purity | >98% |
Storage | at -20°C 3 years Powder |
CAS No. | 848141-11-7 |
Synonyms | AZD9668,AZD 9668,AZD-9668 |
SMILES | CC1=C(C=C(C(=O)N1C2=CC=CC(=C2)C(F)(F)F)C(=O)NCC3=NC=C(C=C3)S(=O)(=O)C)C4=CC=NN4C |
Avelestat,也称为AZD9668,是可口服的,高度选择性neutrophil elastase (NE)抑制剂,IC50和Ki分别为12 nM和9.4 nM,其选择性超过其他丝氨酸蛋白酶至少600倍。
Targets
neutrophil elastase | neutrophil elastase | |||
9.4 nM(Ki) | 12 nM |
In vitro | DMSO | 87 mg/mL (159.47 mM) | |
Water | Insoluble | ||
Ethanol | Insoluble | ||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 18.33 mL | 91.66 mL | 183.32 mL |
0.5 mM | 3.67 mL | 18.33 mL | 36.66 mL |
1 mM | 1.83 mL | 9.17 mL | 18.33 mL |
5 mM | 0.37 mL | 1.83 mL | 3.67 mL |
*The above data is based on the productmolecular weight 545.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.