SB 334867
Catalog No. A12786
SB 334867是一种选择性的非肽orexin OX1受体拮抗剂。对于分别表达人OX1和OX2受体的CHO细胞中的细胞内Ca2 +释放抑制,pKb值为7.2和<5。体内全身给药后,阻断orexin-A诱导的美容和进食。
- Tony Ngo, .et al. Orphan receptor ligand discovery by pickpocketing pharmacological neighbors, Nat Chem Biol, 2017, Feb; 13(2): 235-242 PMID: 27992882
Catalog Num | A12786 |
---|---|
M. Wt | 319.32 |
Formula | C17H13N5O2 |
Purity | >98% |
Storage | at -20°C 3 years Powder |
CAS No. | 249889-64-3 |
Synonyms | SB334867,SB-334867 |
SMILES | CC1=NC2=C(O1)C=C(C=C2)NC(=O)NC3=C4C(=NC=C3)C=CC=N4 |
SB 334867是一种选择性的非肽orexin OX1受体拮抗剂。对于分别表达人OX1和OX2受体的CHO细胞中的细胞内Ca2 +释放抑制,pKb值为7.2和<5。体内全身给药后,阻断orexin-A诱导的美容和进食。
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 31.32 mL | 156.58 mL | 313.17 mL |
0.5 mM | 6.26 mL | 31.32 mL | 62.63 mL |
1 mM | 3.13 mL | 15.66 mL | 31.32 mL |
5 mM | 0.63 mL | 3.13 mL | 6.26 mL |
*The above data is based on the productmolecular weight 319.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.