GSK2578215A

Catalog No. A12798

GSK2578215A是一种有效的富含亮氨酸的重复激酶2（LRRK2）抑制剂（LRRK2 [G2019S]突变体和野生型LRRK2的IC50值分别为8.9和10.1 nM）。

Technical details

Catalog Num	A12798
M. Wt	399.42
Formula	C24H18FN3O2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1285515-21-0
Synonyms	GSK-2578215A, GSK 2578215A
SMILES	C1=CC=C(C=C1)COC2=C(C=C(C=C2)C3=CC(=NC=C3)F)C(=O)NC4=CN=CC=C4

Biological Activity

GSK2578215A是一种有效的富含亮氨酸的重复激酶2（LRRK2）抑制剂（LRRK2 [G2019S]突变体和野生型LRRK2的IC50值分别为8.9和10.1 nM）。

Targets

LRRK2 (G2019S)	LRRK2 (WT)
8.9 nM	10.9 nM

Solubility *

In vitro	DMSO	Warmed: 73 mg/mL (182.76 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	25.04 mL	125.18 mL	250.36 mL
0.5 mM	5.01 mL	25.04 mL	50.07 mL
1 mM	2.5 mL	12.52 mL	25.04 mL
5 mM	0.5 mL	2.5 mL	5.01 mL

*The above data is based on the productmolecular weight 399.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.