Chaetocin

Catalog No. A12812

Chaetocin是组蛋白甲基转移酶SUV39H1抑制剂（IC50 = 0.8μM）。在体外诱导骨髓瘤细胞系的凋亡；在小鼠骨髓瘤模型中具有抗增殖活性。

Technical details

Catalog Num	A12812
M. Wt	696.84
Formula	C30H28N6O6S4
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	28097-03-2
Synonyms
SMILES	CN1C(=O)C23CC4(C(N2C(=O)C1(SS3)CO)NC5=CC=CC=C54)C67CC89C(=O)N(C(C(=O)N8C6NC1=CC=CC=C71)(SS9)CO)C

Biological Activity

Chaetocin是组蛋白甲基转移酶SUV39H1抑制剂（IC50 = 0.8μM）。在体外诱导骨髓瘤细胞系的凋亡；在小鼠骨髓瘤模型中具有抗增殖活性。

Targets

dSU(VAR)3-9	mouse G9a	Neurospora crassa DIM5
0.8 μM	2.5 μM	3 μM

Solubility *

In vitro	DMSO	Warmed: 87 mg/mL (124.85 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	14.35 mL	71.75 mL	143.5 mL
0.5 mM	2.87 mL	14.35 mL	28.7 mL
1 mM	1.44 mL	7.18 mL	14.35 mL
5 mM	0.29 mL	1.44 mL	2.87 mL

*The above data is based on the productmolecular weight 696.84. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.