C646
Catalog No. A12815
C646是选择性的p300/CREB结合蛋白(CBP)抑制剂(Ki = 400 nM)。
- Zhifeng Zhang, .et al. XRCC5 cooperates with p300 to promote cyclooxygenase-2 expression and tumor growth in colon cancers, PLoS One, 2017, 12(10): e0186900 PMID: 29049411
Catalog Num | A12815 |
---|---|
M. Wt | 445.42 |
Formula | C24H19N3O6 |
Purity | >98% |
Storage | at -20°C 3 years Powder |
CAS No. | 328968-36-1 |
Synonyms | C 646, C-646 |
SMILES | CC1=C(C=C(C(=C1)C2=CC=C(O2)/C=C\3/C(=NN(C3=O)C4=CC=C(C=C4)C(=O)O)C)[N+](=O)[O-])C |
C646是选择性的p300/CREB结合蛋白(CBP)抑制剂(Ki = 400 nM)。
Targets
p300/CBP (Cell-free assay) | ||||
400 nM(Ki) |
In vitro (25°C) | DMSO | 13 mg/mL (29.18 mM) | |
Water | Insoluble | ||
Ethanol | Insoluble | ||
In vivo | 5% DMSO+40% PEG 300+5%Tween 80+ddH2O | 1 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 22.45 mL | 112.25 mL | 224.51 mL |
0.5 mM | 4.49 mL | 22.45 mL | 44.9 mL |
1 mM | 2.25 mL | 11.23 mL | 22.45 mL |
5 mM | 0.45 mL | 2.25 mL | 4.49 mL |
*The above data is based on the productmolecular weight 445.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.