SCH772984

Catalog No. A12824

SCH772984是一种新型的ERK1/2特异性抑制剂，IC50分别为4 nM和1 nM。

Product Citations

Yuki Shimizu, .et al. Acquired resistance to BRAF inhibitors is mediated by BRAF splicing variants in BRAF V600E mutation-positive colorectal neuroendocrine carcinoma, Cancer Lett, 2022, Sep 1;543 PMID: 35724767
Yajun Li, .et al. Urolithin B suppressed osteoclast activation and reduced bone loss of osteoporosis via inhibiting ERK/NF-??B pathway, Cell Prolif, 2022, Oct;55(10) PMID: 35708050
Sergey A. Dyshlovoy, .et al. Activity of New Synthetic (2-Chloroethylthio)-1,4-naphthoquinones in Prostate Cancer Cells, Pharmaceuticals, 2021, 14(10), 949
Sergey A Dyshlovoy, .et al. Marine alkaloid monanchoxymycalin C: a new specific activator of JNK1/2 kinase with anticancer properties, Sci Rep, 2020, Aug 6;10(1):13178 PMID: 32764580
Guo X, .et al. PDGF-induced migration of synthetic vascular smooth muscle cells through c-Src-activated L-type Ca2+ channels with full-length CaV1.2 C-terminus, Pflugers Arch, 2018, Jun;470(6):909-921 PMID: 29441404
Takuya Hasegawa, .et al. ErbB2 signaling epigenetically suppresses microRNA-205 transcription via Ras/Raf/MEK/ERK pathway in breast cancer, FEBS Open Bio, 2017, Aug; 7(8): 1154-1165 PMID: 28781955

Technical details

Catalog Num	A12824
M. Wt	587.68
Formula	C33H33N9O2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	942183-80-4
Synonyms	SCH-772984, SCH 772984
SMILES	C1CN(C[C@@H]1C(=O)NC2=CC3=C(C=C2)NN=C3C4=CC=NC=C4)CC(=O)N5CCN(CC5)C6=CC=C(C=C6)C7=NC=CC=N7

Biological Activity

SCH772984是一种新型的ERK1/2特异性抑制剂，IC50分别为4 nM和1 nM。

Targets

ERK2 (Cell-free assay)	ERK1 (Cell-free assay)	MEK1 (Cell-free assay)
1 nM	4 nM	>10 μM

Solubility *

In vitro (25°C)	DMSO	Warmed: 13 mg/mL (22.12 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	5% DMSO+30% PEG 300+ddH2O	0.5 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	17.02 mL	85.08 mL	170.16 mL
0.5 mM	3.4 mL	17.02 mL	34.03 mL
1 mM	1.7 mL	8.51 mL	17.02 mL
5 mM	0.34 mL	1.7 mL	3.4 mL

*The above data is based on the productmolecular weight 587.68. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.