GDC-0032 (Taselisib)

Catalog No. A12831

GDC-0032 (Taselisib)是有效的下一代PI3抑制剂，靶向PI3α。

Technical details

Catalog Num	A12831
M. Wt	460.53
Formula	C24H28N8O2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1282512-48-4
Synonyms	GDC 0032, GDC0032
SMILES	CC1=NN(C(=N1)C2=CN3CCOC4=C(C3=N2)C=CC(=C4)C5=CN(N=C5)C(C)(C)C(=O)N)C(C)C

Biological Activity

GDC-0032 (Taselisib)是有效的下一代PI3抑制剂，靶向PI3α。

Targets

Target	Value
PI3Kδ	ki: 0.12nM
PI3Kα	ki: 0.29nM
PI3Kγ	ki: 0.97nM
PI3Kβ	ki: 9.1nM
C2β	IC50: 292nM
hVps34	IC50: 374nM
mTOR	ki: 1.2μM
DNA-PK	IC50: >4.8μM
C2α	IC50: >10μM

Solubility *

In vitro	DMSO	Warmed: 62 mg/mL (134.62 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.71 mL	108.57 mL	217.14 mL
0.5 mM	4.34 mL	21.71 mL	43.43 mL
1 mM	2.17 mL	10.86 mL	21.71 mL
5 mM	0.43 mL	2.17 mL	4.34 mL

*The above data is based on the productmolecular weight 460.53. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.