IKK-16

Catalog No. A12836

IKK 16是针对IKK-2，IKK复合物和IKK-1的选择性IκB激酶（IKK）抑制剂，IC50分别为40 nM，70 nM和200 nM。

Product Citations

Rulina AV, .et al. Distinct outcomes of CRL-Nedd8 pathway inhibition reveal cancer cell plasticity, Cell Death Dis, 2016, Dec 1;7(12):e2505 PMID: 27906189

Technical details

Catalog Num	A12836
M. Wt	483.63
Formula	C28H29N5OS
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	873225-46-8
Synonyms	IKK 16, IKK16
SMILES	C1CCN(C1)C2CCN(CC2)C(=O)C3=CC=C(C=C3)NC4=NC=CC(=N4)C5=CC6=CC=CC=C6S5

Biological Activity

IKK 16是针对IKK-2，IKK复合物和IKK-1的选择性IκB激酶（IKK）抑制剂，IC50分别为40 nM，70 nM和200 nM。

Targets

IKK2 (Cell-free assay)	IKK complex (Cell-free assay)	IKK1 (Cell-free assay)
40 nM	70 nM	200 nM

Solubility *

In vitro (25°C)	DMSO	95 mg/mL (196.42 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	30% PEG400+0.5% Tween80+5% propylene glycol	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	20.68 mL	103.38 mL	206.77 mL
0.5 mM	4.14 mL	20.68 mL	41.35 mL
1 mM	2.07 mL	10.34 mL	20.68 mL
5 mM	0.41 mL	2.07 mL	4.14 mL

*The above data is based on the productmolecular weight 483.63. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.