IMD 0354

Catalog No. A12837

IMD 0354是IκB激酶-β（IKKβ）抑制剂，可阻断NF-κB核易位。

Product Citations

Anton Lennikov, .et al. Selective IKK2 inhibitor IMD0354 disrupts NF-κB signaling to suppress corneal inflammation and angiogenesis, Angiogenesis, 2018, 21(2): 267-285 PMID: 29332242

Technical details

Catalog Num	A12837
M. Wt	383.67
Formula	C15H8ClF6NO2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	978-62-1
Synonyms	IMD-0354, IMD0354
SMILES	C1=CC(=C(C=C1Cl)C(=O)NC2=CC(=CC(=C2)C(F)(F)F)C(F)(F)F)O

Biological Activity

IMD 0354是IκB激酶-β（IKKβ）抑制剂，可阻断NF-κB核易位。

Targets

IKKβ

Solubility *

In vitro (25°C)	DMSO	9 mg/mL (23.45 mM)
	Water	Insoluble
	Ethanol	72 mg/mL (187.66 mM)
In vivo	2% DMSO+5% Tween 80+0.5% CMC Na	2 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	26.06 mL	130.32 mL	260.64 mL
0.5 mM	5.21 mL	26.06 mL	52.13 mL
1 mM	2.61 mL	13.03 mL	26.06 mL
5 mM	0.52 mL	2.61 mL	5.21 mL

*The above data is based on the productmolecular weight 383.67. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.