VTX-2337

Catalog No. A12841

VTX-2337是一种具有潜在的免疫刺激和抗肿瘤活性的小分子Toll样受体8（TLR8）激动剂。

Product Citations

Yinwen Cheng, .et al. The anti-tumor effects of cetuximab in combination with VTX-2337 are T cell dependent, Sci Rep, 2021, Jan 15;11(1):1535 PMID: 33452311

Technical details

Catalog Num	A12841
M. Wt	458.6
Formula	C28H34N4O2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	926927-61-9
Synonyms	VTX2337, VTX 2337
SMILES	CCCN(CCC)C(=O)C1=CC2=C(C=C(C=C2)C3=CC=C(C=C3)C(=O)N4CCCC4)N=C(C1)N

Biological Activity

VTX-2337是一种具有潜在的免疫刺激和抗肿瘤活性的小分子Toll样受体8（TLR8）激动剂。

Targets

TLR8
100 nM(EC50)

Solubility *

In vitro	DMSO	Warmed: 48 mg/mL (104.67 mM)
	Water	Insoluble
	Ethanol	13 mg/mL (28.34 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.81 mL	109.03 mL	218.05 mL
0.5 mM	4.36 mL	21.81 mL	43.61 mL
1 mM	2.18 mL	10.9 mL	21.81 mL
5 mM	0.44 mL	2.18 mL	4.36 mL

*The above data is based on the productmolecular weight 458.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.