OTSSP167

Catalog No. A12851

OTSSP167是一种高效的MELK（母体亮氨酸拉链激酶）抑制剂，IC50为0.41 nM。

Product Citations

Yubao Wang ,etc. Mitotic MELK-eIF4B signaling controls protein synthesis and tumor cell survival. Proc Natl Acad Sci USA. 2016 Aug 30; 113(35): 9810–9815.

Technical details

Catalog Num	A12851
M. Wt	487.42
Formula	C25H28Cl2N4O2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1431697-89-0
Synonyms	OTSSP-167, OTSSP 167
SMILES	CC(=O)C1=CN=C2C=CC(=C3C=C(C(=O)C(=C3)Cl)Cl)NC2=C1NC4CCC(CC4)CN(C)C

Biological Activity

OTSSP167是一种高效的MELK（母体亮氨酸拉链激酶）抑制剂，IC50为0.41 nM。

Targets

MELK
0.41 nM

Solubility *

In vitro	DMSO	Warmed: 0.47 mg/mL (0.96 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	20.52 mL	102.58 mL	205.16 mL
0.5 mM	4.1 mL	20.52 mL	41.03 mL
1 mM	2.05 mL	10.26 mL	20.52 mL
5 mM	0.41 mL	2.05 mL	4.1 mL

*The above data is based on the productmolecular weight 487.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.