Mirabegron

Catalog No. A12861

Mirabegron是一种选择性的beta3-adrenoceptor（β3肾上腺素受体）激动剂，EC50为22.4 nM。是有效的膀胱松弛药和糖尿病药物。

Product Citations

Bhavik Patel, .et al. Combination drug therapy against OAB normalizes micturition parameters and increases the release of nitric oxide during chemically induced cystitis, Pharmacol Res Perspect, 2020, 8 (1), e00564 PMID: 32030913

Technical details

Catalog Num	A12861
M. Wt	396.51
Formula	C21H24N4O2S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	223673-61-8
Synonyms
SMILES	C1=CC=C(C=C1)[C@H](CNCCC2=CC=C(C=C2)NC(=O)CC3=CSC(=N3)N)O

Biological Activity

Mirabegron是一种选择性的beta3-adrenoceptor（β3肾上腺素受体）激动剂，EC50为22.4 nM。是有效的膀胱松弛药和糖尿病药物。

Targets

β3-adrenoceptor
22.4 nM(EC50)

Solubility *

In vitro (25°C)	DMSO	70 mg/mL (176.53 mM)
	Water	Insoluble
	Ethanol	7 mg/mL (17.65 mM)
In vivo	2% DMSO+30% PEG 300+ddH2O	10 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	25.22 mL	126.1 mL	252.2 mL
0.5 mM	5.04 mL	25.22 mL	50.44 mL
1 mM	2.52 mL	12.61 mL	25.22 mL
5 mM	0.5 mL	2.52 mL	5.04 mL

*The above data is based on the productmolecular weight 396.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.