AGI-5198 (IDH-C35)

Catalog No. A12902

AGI-5198 (IDH-C35)是一种非常有效的选择性IDH1突变抑制剂，具有潜在的抗癌活性。

Technical details

Catalog Num	A12902
M. Wt	462.56
Formula	C27H31FN4O2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1355326-35-0
Synonyms	AGI5198,AGI 5198, IDHC35
SMILES	CC1=CC=CC=C1C(C(=O)NC2CCCCC2)N(C3=CC(=CC=C3)F)C(=O)CN4C=CN=C4C

Biological Activity

AGI-5198 (IDH-C35)是一种非常有效的选择性IDH1突变抑制剂，具有潜在的抗癌活性。

Targets

R132H-IDH1	R132C-IDH1
70 nM	0.16 μM

Solubility *

In vitro (25°C)	DMSO	22 mg/mL (47.56 mM)
	Water	Insoluble
	Ethanol	13 mg/mL (28.1 mM)
In vivo	0.5% methylcellulose+0.2% Tween 80	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.62 mL	108.09 mL	216.19 mL
0.5 mM	4.32 mL	21.62 mL	43.24 mL
1 mM	2.16 mL	10.81 mL	21.62 mL
5 mM	0.43 mL	2.16 mL	4.32 mL

*The above data is based on the productmolecular weight 462.56. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.