AM251
Catalog No. A12914
AM251是有效的CB1受体拮抗剂(IC50 = 8 nM,Ki = 7.49 nM),其选择性是CB2受体的306倍。
Catalog Num | A12914 |
---|---|
M. Wt | 555.24 |
Formula | C22H21Cl2IN4O |
Purity | >98% |
Storage | at -20°C 3 years Powder |
CAS No. | 183232-66-8 |
Synonyms | AM 251, AM-251 |
SMILES | CC1=C(N(N=C1C(=O)NN2CCCCC2)C3=C(C=C(C=C3)Cl)Cl)C4=CC=C(C=C4)I |
AM251是有效的CB1受体拮抗剂(IC50 = 8 nM,Ki = 7.49 nM),其选择性是CB2受体的306倍。
Targets
CB1 | ||||
In vitro (25°C) | DMSO | 39 mg/mL (70.24 mM) | |
Water | Insoluble | ||
Ethanol | Insoluble | ||
In vivo | 1% DMSO+30% polyethylene glycol+1% Tween 80 | 7 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 18.01 mL | 90.05 mL | 180.1 mL |
0.5 mM | 3.6 mL | 18.01 mL | 36.02 mL |
1 mM | 1.8 mL | 9.01 mL | 18.01 mL |
5 mM | 0.36 mL | 1.8 mL | 3.6 mL |
*The above data is based on the productmolecular weight 555.24. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.