MI-2 (Menin-MLL inhibitor 2)

Catalog No. A12929

MI-2 (Menin-MLL inhibitor 2)特异性结合menin并抑制menin与细胞中mll融合蛋白的相互作用。它能有效逆转mll融合蛋白通过下调mll融合蛋白致癌活性下游靶基因的表达来介导白血病转化。mi-2是更好地理解mll介导的白血病发生的新工具，代表了研究menin作为mll融合蛋白致癌辅助因子的作用的新方法。

Technical details

Catalog Num	A12929
M. Wt	375.55
Formula	C18H25N5S2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1271738-62-5
Synonyms	Menin-MLL inhibitor 2
SMILES	CCCC1=CC2=C(N=CN=C2S1)N3CCN(CC3)C4=NCC(S4)(C)C

Biological Activity

Targets

Menin-MLL	Menin-MLL
N/A	446 nM

Solubility *

In vitro (25°C)	DMSO	Warmed: 71 mg/mL (189.05 mM)
	Water	Insoluble
	Ethanol	71 mg/mL (189.05 mM)
In vivo	2% DMSO+30% PEG 300+2% Tween 80+ddH2O	2 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	26.63 mL	133.14 mL	266.28 mL
0.5 mM	5.33 mL	26.63 mL	53.26 mL
1 mM	2.66 mL	13.31 mL	26.63 mL
5 mM	0.53 mL	2.66 mL	5.33 mL

*The above data is based on the productmolecular weight 375.55. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.