Wnt-C59

Catalog No. A12951

Wnt-C59是一种非常有效且高度选择性的Wnt信号拮抗剂，在Wnt信号报告基因分析中的IC50?74 pM。

Product Citations

Laksitorini MD, .et al. Modulation of Wnt/β-catenin signaling promotes blood-brain barrier phenotype in cultured brain endothelial cells, Sci Rep, 2019, Dec 23;9(1):19718 PMID: 31873116

Technical details

Catalog Num	A12951
M. Wt	379.45
Formula	C25H21N3O
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1243243-89-1
Synonyms	WntC59
SMILES	CC1=NC=CC(=C1)C2=CC=C(C=C2)CC(=O)NC3=CC=C(C=C3)C4=CN=CC=C4

Biological Activity

Wnt-C59是一种非常有效且高度选择性的Wnt信号拮抗剂，在Wnt信号报告基因分析中的IC50?74 pM。

Targets

Porcn (HEK293 cells )
74 pM

Solubility *

In vitro (25°C)	DMSO	71 mg/mL (187.1 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	2% DMSO+30% PEG 300+5% Tween 80+ddH2O	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	26.35 mL	131.77 mL	263.54 mL
0.5 mM	5.27 mL	26.35 mL	52.71 mL
1 mM	2.64 mL	13.18 mL	26.35 mL
5 mM	0.53 mL	2.64 mL	5.27 mL

*The above data is based on the productmolecular weight 379.45. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.