Monomethyl auristatin E

Catalog No. A12954

Monomethyl auristatin E是一种抗有丝分裂剂，可通过阻止微管蛋白的聚合来抑制细胞分裂，并且还表现出对抗体-药物偶联物（ADCs）活性的抑制作用。

Product Citations

Sochaj-Gregorczyk AM, .et al. A Novel Affibody-Auristatin E Conjugate With a Potent and Selective Activity Against HER2+ Cell Lines, J Immunother, 2016, Jul-Aug;39(6):223-32 PMID: 27227324

Technical details

Catalog Num	A12954
M. Wt	717.98
Formula	C39H67N5O7
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	474645-27-7
Synonyms	Monomethylauristatin E, MMAE
SMILES	CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@@H]([C@@H](C)C(=O)N[C@H](C)[C@H](C2=CC=CC=C2)O)OC)OC)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)NC

Biological Activity

Monomethyl auristatin E是一种抗有丝分裂剂，可通过阻止微管蛋白的聚合来抑制细胞分裂，并且还表现出对抗体-药物偶联物（ADCs）活性的抑制作用。

Solubility *

In vitro	DMSO	93 mg/mL (129.52 mM)
	Water	Insoluble
	Ethanol	93 mg/mL (129.52 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	13.93 mL	69.64 mL	139.28 mL
0.5 mM	2.79 mL	13.93 mL	27.86 mL
1 mM	1.39 mL	6.96 mL	13.93 mL
5 mM	0.28 mL	1.39 mL	2.79 mL

*The above data is based on the productmolecular weight 717.98. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.