Batimastat (BB-94)
Catalog No. A12985
Batimastat (BB-94)是多种基质金属蛋白酶(MMP)的强效合成抑制剂,包括间质胶原酶(IC50 = 3 nM),溶血素(IC50 = 20 nM),Mr 72,000型IV胶原酶(IC50 = 4) nM),92,000型IV胶原酶先生(IC50 = 4 nM)和基质溶素(IC50 = 6 nM)。它是一种低分子量(MW = 478)的肽样胶原蛋白底物类似物,由类似物结合而成,分别与MMP和催化活性锌原子结合在一起。
Catalog Num | A12985 |
---|---|
M. Wt | 477.64 |
Formula | C23H31N3O4S2 |
Purity | >98% |
Storage | at -20°C 3 years Powder |
CAS No. | 130370-60-4 |
Synonyms | BB 94 |
SMILES | CC(C)C[C@H]([C@H](CSC1=CC=CS1)C(=O)NO)C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)NC |
Batimastat (BB-94)是多种基质金属蛋白酶(MMP)的强效合成抑制剂,包括间质胶原酶(IC50 = 3 nM),溶血素(IC50 = 20 nM),Mr 72,000型IV胶原酶(IC50 = 4) nM),92,000型IV胶原酶先生(IC50 = 4 nM)和基质溶素(IC50 = 6 nM)。它是一种低分子量(MW = 478)的肽样胶原蛋白底物类似物,由类似物结合而成,分别与MMP和催化活性锌原子结合在一起。
Targets
MMP-1 | MMP-2 | MMP-9 | MMP-7 | MMP-3 |
3 nM | 4 nM | 4 nM | 6 nM | 20 nM |
In vitro (25°C) | DMSO | 84 mg/mL (175.86 mM) | |
Water | Insoluble | ||
Ethanol | Insoluble | ||
In vivo | 2% DMSO+40% PEG 300+2% Tween 80+ddH2O | 1 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 20.94 mL | 104.68 mL | 209.36 mL |
0.5 mM | 4.19 mL | 20.94 mL | 41.87 mL |
1 mM | 2.09 mL | 10.47 mL | 20.94 mL |
5 mM | 0.42 mL | 2.09 mL | 4.19 mL |
*The above data is based on the productmolecular weight 477.64. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.