LDC1267

Catalog No. A13003

LDC1267是一种高选择性TAM（Tyro3，Axl和Mer）激酶抑制剂，对于Tyro3，Axl和Mer的IC50分别小于5 nM/8 nM/29 nM。

Technical details

Catalog Num	A13003
M. Wt	560.55
Formula	C30H26F2N4O5
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1361030-48-9
Synonyms	LDC 1267, LDC-1267
SMILES	CCOC1=CN(N=C1C(=O)NC2=CC(=C(C=C2)OC3=C4C=C(C(=CC4=NC=C3)OC)OC)F)C5=C(C=C(C=C5)F)C

Biological Activity

LDC1267是一种高选择性TAM（Tyro3，Axl和Mer）激酶抑制剂，对于Tyro3，Axl和Mer的IC50分别小于5 nM/8 nM/29 nM。

Targets

Mer	Tyro3	Axl
<5 nM	8 nM	29 nM

Solubility *

In vitro	DMSO	Warmed: 89 mg/mL (158.77 mM)
	Water	Insoluble
	Ethanol	Warmed: 2 mg/mL (3.56 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	17.84 mL	89.2 mL	178.4 mL
0.5 mM	3.57 mL	17.84 mL	35.68 mL
1 mM	1.78 mL	8.92 mL	17.84 mL
5 mM	0.36 mL	1.78 mL	3.57 mL

*The above data is based on the productmolecular weight 560.55. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.