Beta-Lapachone

Catalog No. A13059

Beta-Lapachone是一种选择性的DNA拓扑异构酶I抑制剂，对DNA拓扑异构酶II或连接酶没有抑制活性。

Product Citations

Xiaoling Li, .et al. Nanozyme-Augmented Tumor Catalytic Therapy by Self-Supplied H2O2 Generation, ACS Appl. Bio Mater, 2020, 3, 3, 1769-1778

Technical details

Catalog Num	A13059
M. Wt	242.27
Formula	C15H14O3
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	4707-32-8
Synonyms	ARQ-501
SMILES	CC1(CCC2=C(O1)C3=CC=CC=C3C(=O)C2=O)C

Biological Activity

Beta-Lapachone是一种选择性的DNA拓扑异构酶I抑制剂，对DNA拓扑异构酶II或连接酶没有抑制活性。

Targets

Topo I	IDO1
N/A	0.44 μM

Solubility *

In vitro	DMSO	Warmed: 29 mg/mL (119.7 mM)
	Water	Insoluble
	Ethanol	9 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	41.28 mL	206.38 mL	412.76 mL
0.5 mM	8.26 mL	41.28 mL	82.55 mL
1 mM	4.13 mL	20.64 mL	41.28 mL
5 mM	0.83 mL	4.13 mL	8.26 mL

*The above data is based on the productmolecular weight 242.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.