RKI-1447

Catalog No. A13067

RKI-1447是Rho相关ROCK激酶的有效抑制剂，在乳腺癌中具有抗侵袭和抗肿瘤活性。

Technical details

Catalog Num	A13067
M. Wt	326.37
Formula	C16H14N4O2S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1342278-01-6
Synonyms	RKI1447; RKI 1447. ROCK Inhibitor XIII
SMILES	C1=CC(=CC(=C1)O)CNC(=O)NC2=NC(=CS2)C3=CC=NC=C3

Biological Activity

RKI-1447是Rho相关ROCK激酶的有效抑制剂，在乳腺癌中具有抗侵袭和抗肿瘤活性。

Targets

ROCK2	ROCK1
6.2 nM	14.5 nM

Solubility *

In vitro (25°C)	DMSO	62 mg/mL (189.97 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	15% Captisol	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	30.64 mL	153.2 mL	306.4 mL
0.5 mM	6.13 mL	30.64 mL	61.28 mL
1 mM	3.06 mL	15.32 mL	30.64 mL
5 mM	0.61 mL	3.06 mL	6.13 mL

*The above data is based on the productmolecular weight 326.37. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.