LY573636 (Tasisulam)

Catalog No. A13070

LY573636 (Tasisulam)是一种有效的抗肿瘤剂，在体外和体内引起多种人实体瘤的生长停滞和凋亡。LY573636诱导的凋亡通过线粒体靶向机制发生。

Product Citations

Ting TC, .et al. Aryl Sulfonamides Degrade RBM39 and RBM23 by Recruitment to CRL4-DCAF15, Cell Rep, 2019, Nov 5;29(6):1499-1510.e6 PMID: 31693891
Ting Han, .et al. Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15, Science, 2017, Apr 28;356(6336). pii: eaal3755 PMID: 28302793

Technical details

Catalog Num	A13070
M. Wt	415.11
Formula	C11H6BrCl2NO3S2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	519055-62-0
Synonyms	LY 573636, LY-573636
SMILES	C1=CC(=C(C=C1Cl)Cl)C(=O)NS(=O)(=O)C2=CC=C(S2)Br

Biological Activity

LY573636 (Tasisulam)是一种有效的抗肿瘤剂，在体外和体内引起多种人实体瘤的生长停滞和凋亡。LY573636诱导的凋亡通过线粒体靶向机制发生。

Targets

Caspase

Solubility *

In vitro	DMSO	73 mg/mL (175.85 mM)
	Water	Insoluble
	Ethanol	73 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	24.09 mL	120.45 mL	240.9 mL
0.5 mM	4.82 mL	24.09 mL	48.18 mL
1 mM	2.41 mL	12.05 mL	24.09 mL
5 mM	0.48 mL	2.41 mL	4.82 mL

*The above data is based on the productmolecular weight 415.11. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.