NSC 405020

Catalog No. A13072

NSC-405020是一种膜1型基质金属蛋白酶（MT1-MMP）抑制剂（IC50> 100μmol/ L）。

Product Citations

Kittaka M, .et al. Cherubism Mice Also Deficient in c-Fos Exhibit Inflammatory Bone Destruction Executed by Macrophages That Express MMP14 Despite the Absence of TRAP+ Osteoclasts, J Bone Miner Res, 2018, Jan;33(1):167-181 PMID: 28914985

Technical details

Catalog Num	A13072
M. Wt	260.16
Formula	C12H15Cl2NO
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	CAS: 7497-07-6
Synonyms	NSC405020, NSC-405020
SMILES	CCCC(C)NC(=O)C1=CC(=C(C=C1)Cl)Cl

Biological Activity

NSC-405020是一种膜1型基质金属蛋白酶（MT1-MMP）抑制剂（IC50> 100μmol/ L）。

Targets

MT1-MMP

Solubility *

In vitro (25°C)	DMSO	48 mg/mL (184.5 mM)
	Water	Insoluble
	Ethanol	48 mg/mL (184.5 mM)
In vivo	1% DMSO+30% polyethylene glycol+1% Tween 80	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	38.44 mL	192.19 mL	384.38 mL
0.5 mM	7.69 mL	38.44 mL	76.88 mL
1 mM	3.84 mL	19.22 mL	38.44 mL
5 mM	0.77 mL	3.84 mL	7.69 mL

*The above data is based on the productmolecular weight 260.16. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.