CC-223

Catalog No. A13078

CC-223是一种有效的mTOR激酶抑制剂（IC50 = 16 nM），其敏感性是相关脂质激酶PI3K-alpha（IC50 = 4 uM）的> 150倍。

Technical details

Catalog Num	A13078
M. Wt	397.47
Formula	C21H27N5O3
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1228013-30-6
Synonyms	CC 223, CC223
SMILES	CC(C)(C1=NC=C(C=C1)C2=CN=C3C(=N2)N(C(=O)CN3)C4CCC(CC4)OC)O

Biological Activity

CC-223是一种有效的mTOR激酶抑制剂（IC50 = 16 nM），其敏感性是相关脂质激酶PI3K-alpha（IC50 = 4 uM）的> 150倍。

Targets

mTOR	cFMS	FLT4	DNA-PK	PI3K-α
16 nM	28 nM	651 nM	840 nM	4.0 μM

Solubility *

In vitro	DMSO	70 mg/mL (176.11 mM)
	Water	Insoluble
	Ethanol	70 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	25.16 mL	125.8 mL	251.59 mL
0.5 mM	5.03 mL	25.16 mL	50.32 mL
1 mM	2.52 mL	12.58 mL	25.16 mL
5 mM	0.5 mL	2.52 mL	5.03 mL

*The above data is based on the productmolecular weight 397.47. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.