Kobe0065

Catalog No. A13135

Kobe0065抑制锚定依赖性和非依赖性生长，阻断MEK / ERK活性并诱导H-rasG12V转化的NIH3T3细胞凋亡。

Technical details

Catalog Num	A13135
M. Wt	449.79
Formula	C15H11ClF3N5O4S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	436133-68-5
Synonyms	Kobe-0065
SMILES	CC1=C(C=C(C=C1)NC(=S)NNC2=C(C=C(C=C2[N+](=O)[O-])C(F)(F)F)[N+](=O)[O-])Cl

Biological Activity

Kobe0065抑制锚定依赖性和非依赖性生长，阻断MEK / ERK活性并诱导H-rasG12V转化的NIH3T3细胞凋亡。

Targets

H-Ras-cRaf1 interaction

Solubility *

In vitro	DMSO	85 mg/mL (188.98 mM)
	Water	Insoluble
	Ethanol	12 mg/mL (26.68 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.23 mL	111.16 mL	222.33 mL
0.5 mM	4.45 mL	22.23 mL	44.47 mL
1 mM	2.22 mL	11.12 mL	22.23 mL
5 mM	0.44 mL	2.22 mL	4.45 mL

*The above data is based on the productmolecular weight 449.79. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.