PND-1186

Catalog No. A13140

PND-1186是一种强效fak抑制剂，ic50为1.5 nm。

Technical details

Catalog Num	A13140
M. Wt	501.5
Formula	C25H26F3N5O3
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1061353-68-1
Synonyms	SR-2516, PND 1186, PND1186, SR 2516, SR2516
SMILES	CNC(=O)C1=CC=CC=C1NC2=CC(=NC=C2C(F)(F)F)NC3=C(C=C(C=C3)N4CCOCC4)OC

Biological Activity

PND-1186是一种强效fak抑制剂，ic50为1.5 nm。

Targets

FAK
0.5 nM

Solubility *

In vitro (25°C)	DMSO	22 mg/mL (43.86 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	2% DMSO+30% PEG 300+5% Tween 80+ddH2O	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.94 mL	99.7 mL	199.4 mL
0.5 mM	3.99 mL	19.94 mL	39.88 mL
1 mM	1.99 mL	9.97 mL	19.94 mL
5 mM	0.4 mL	1.99 mL	3.99 mL

*The above data is based on the productmolecular weight 501.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.