CL-387785 (EKI-785)

Catalog No. A13146

CL-387785是EGFR的不可逆抑制剂，IC50为370+/-120 pM；能够在功能水平上克服由T790M突变引起的抗药性。

Technical details

Catalog Num	A13146
M. Wt	381.23
Formula	C18H13BrN4O
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	194423-06-8
Synonyms	WAY-EKI 785, CL387785, CL 387785, EKI785, WAY-EKI785, EKI 785, EKI-785
SMILES	CC#C/C(O)=N/C1=CC(C(NC2=CC=CC(Br)=C2)=NC=N3)=C3C=C1

Biological Activity

CL-387785是EGFR的不可逆抑制剂，IC50为370+/-120 pM；能够在功能水平上克服由T790M突变引起的抗药性。

Targets

EGFR
370 pM

Solubility *

In vitro	DMSO	Warmed: 61 mg/mL (160 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	26.23 mL	131.15 mL	262.31 mL
0.5 mM	5.25 mL	26.23 mL	52.46 mL
1 mM	2.62 mL	13.12 mL	26.23 mL
5 mM	0.52 mL	2.62 mL	5.25 mL

*The above data is based on the productmolecular weight 381.23. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.