XEN445

Catalog No. A13150

XEN445是内皮脂肪酶(EL)抑制剂，IC50为0.237 uM，具有很好的ADME和PK活性，能提高小鼠血浆中高密度脂蛋白胆固醇浓度。

Technical details

Catalog Num	A13150
M. Wt	366.33
Formula	C18H17F3N2O3
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1515856-92-4
Synonyms	XEN-445, XEN 445
SMILES	C1CN(CC1OCC2=CC=CC=N2)C3=C(C=C(C=C3)C(F)(F)F)C(=O)O

Biological Activity

XEN445是内皮脂肪酶(EL)抑制剂，IC50为0.237 uM，具有很好的ADME和PK活性，能提高小鼠血浆中高密度脂蛋白胆固醇浓度。

Targets

Solubility *

Targets

endothelial lipase
0.237 μM

In vitro	DMSO	79 mg/mL (215.65 mM)
	Water	Insoluble
	Ethanol	Warmed: 34 mg/mL (92.81 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	27.3 mL	136.49 mL	272.98 mL
0.5 mM	5.46 mL	27.3 mL	54.6 mL
1 mM	2.73 mL	13.65 mL	27.3 mL
5 mM	0.55 mL	2.73 mL	5.46 mL

*The above data is based on the productmolecular weight 366.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Adooq Bioscience

XEN445

Technical details

Biological Activity

Targets

Solubility *

Preparing Stock Solutions