AZD1208

Catalog No. A13203

AZD1208是PIM激酶的小分子抑制剂,具有潜在的抗肿瘤活性。
  • Remy J, .et al. Inhibition of PIM1 blocks the autophagic flux to sensitize glioblastoma cells to ABT-737-induced apoptosis, Biochim Biophys Acta Mol Cell Res, 2019, Feb;1866(2):175-189 PMID: 30389373
  • Andrea L. Casillas, .et al. Hypoxia-inducible PIM kinase expression promotes resistance to anti-angiogenic agents, Clin Cancer Res, 2018, Jan 1; 24(1): 169-180 PMID: 29084916
  • Jin H. Song, .et al. Mechanisms Behind Resistance to PI3K Inhibitor Treatment Induced by the PIM Kinase, Mol Cancer Ther, 2018, Dec;17(12):2710-2721 PMID: 30190422
  • Sathish K.R. Padi, .et al. Targeting the PIM protein kinases for the treatment of a T-cell acute lymphoblastic leukemia subset, Oncotarget, 2017, May 2; 8(18): 30199-30216 PMID: 28415816
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Catalog Num A13203
M. Wt 379.48
Formula C21H21N3O2S
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1204144-28-4
Synonyms AZD 1208, AZD-1208
SMILES C1C[C@H](CN(C1)C2=C(C=CC=C2/C=C\3/C(=O)NC(=O)S3)C4=CC=CC=C4)N
AZD1208是PIM激酶的小分子抑制剂,具有潜在的抗肿瘤活性。
Targets
Pim1 (Cell-free assay) Pim3 (Cell-free assay) Pim2 (Cell-free assay)
0.4 nM1.9 nM5 nM
In vitro DMSO Warmed: 70 mg/mL (184.45 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 26.35 mL 131.76 mL 263.52 mL
0.5 mM 5.27 mL 26.35 mL 52.7 mL
1 mM 2.64 mL 13.18 mL 26.35 mL
5 mM 0.53 mL 2.64 mL 5.27 mL

*The above data is based on the productmolecular weight 379.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.