KU 0060648
Catalog No. A13224
KU0060648是一种有效且选择性的DNA依赖性蛋白激酶（DNA-PK）抑制剂（IC50 = 8.6 nM）；对DNA-PK的选择性是其他PIKK的20-1000倍，并且有60种激酶。KU-0060648可提高HDR效率并衰减NHEJ频率。
| Catalog Num | A13224 |
|---|---|
| M. Wt | 692.1 |
| Formula | C33H34N4O4S.3HCl |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 881375-00-4 |
| Synonyms | KU0060648, KU-0060648 |
| SMILES | CCN1CCN(CC1)CC(=O)NC2=C3C4=CC=CC=C4SC3=C(C=C2)C5=CC=CC6=C5OC(=CC6=O)N7CCOCC7 |
KU0060648是一种有效且选择性的DNA依赖性蛋白激酶（DNA-PK）抑制剂（IC50 = 8.6 nM）；对DNA-PK的选择性是其他PIKK的20-1000倍，并且有60种激酶。KU-0060648可提高HDR效率并衰减NHEJ频率。
| In vitro (25°C) | DMSO | 0.39 mg/mL (0.66 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 30% propylene glycol, 5% Tween 80, 65% D5W | 19 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 14.45 mL | 72.24 mL | 144.49 mL |
| 0.5 mM | 2.89 mL | 14.45 mL | 28.9 mL |
| 1 mM | 1.44 mL | 7.22 mL | 14.45 mL |
| 5 mM | 0.29 mL | 1.44 mL | 2.89 mL |
*The above data is based on the productmolecular weight 692.1. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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