Actinomycin D
Catalog No. A13239
Actinomycin D是从小链霉菌中分离出来的一种代谢产物，与DNA的GpC步骤结合。抑制 DNA 修复，IC50 为 0.42 μM。该化合物可作为抗生素，并且比革兰氏阴性细菌更有效地抵抗革兰氏阳性细菌。
- Chauhan D, .et al. BAX/BAK-Induced Apoptosis Results in Caspase-8-Dependent IL-1β Maturation in Macrophages, Cell Rep, 2018, Nov 27;25(9):2354-2368.e5 PMID: 30485805
| Catalog Num | A13239 |
|---|---|
| M. Wt | 1255.4 |
| Formula | C62H86N12O16 |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 50-76-0 |
| Synonyms | Actinomycin-D |
| SMILES | CC1C(C(=O)NC(C(=O)N2CCCC2C(=O)N(CC(=O)N(C(C(=O)O1)C(C)C)C)C)C(C)C)NC(=O)C3=C4C(=C(C=C3)C)OC5=C(C(=O)C(=C(C5=N4)C(=O)NC6C(OC(=O)C(N(C(=O)CN(C(=O)C7CCCN7C(=O)C(NC6=O)C(C)C)C)C)C(C)C)C)N)C |
Actinomycin D是从小链霉菌中分离出来的一种代谢产物，与DNA的GpC步骤结合。抑制 DNA 修复，IC50 为 0.42 μM。该化合物可作为抗生素，并且比革兰氏阴性细菌更有效地抵抗革兰氏阳性细菌。
| In vitro | DMSO | 91 mg/mL (72.48 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 7.97 mL | 39.83 mL | 79.66 mL |
| 0.5 mM | 1.59 mL | 7.97 mL | 15.93 mL |
| 1 mM | 0.8 mL | 3.98 mL | 7.97 mL |
| 5 mM | 0.16 mL | 0.8 mL | 1.59 mL |
*The above data is based on the productmolecular weight 1255.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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