GM 6001

Catalog No. A13320

GM 6001是一种有效的，可逆的广谱抑制剂，用于含锌的蛋白酶，包括基质金属蛋白酶（MMP）。

Technical details

Catalog Num	A13320
M. Wt	388.5
Formula	C20H28N4O4
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	142880-36-2
Synonyms	Galardin, Ilomastat, GM-6001
SMILES	CC(C)C[C@H](CC(=O)NO)C(=O)N[C@@H](CC1=CNC2=CC=CC=C21)C(=O)NC

Biological Activity

GM 6001是一种有效的，可逆的广谱抑制剂，用于含锌的蛋白酶，包括基质金属蛋白酶（MMP）。

Targets

Target	Value
MMP-8	ki: 0.1nM
MMP-9	ki: 0.2nM
MMP-26	ki: 0.36nM
MMP-1	ki: 0.4nM
MMP-2	ki: 0.5nM
MMP-12	ki: 3.6nM
MMP-7	ki: 3.7nM
MMP-14	ki: 13.4nM
MMP-3	ki: 27nM

Solubility *

In vitro (25°C)	DMSO	73 mg/mL (187.92 mM)
	Water	Insoluble
	Ethanol	Warmed: 7 mg/mL (18.02 mM)
In vivo	2% DMSO+40% PEG 300+2% Tween 80+ddH2O	10 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	25.74 mL	128.7 mL	257.4 mL
0.5 mM	5.15 mL	25.74 mL	51.48 mL
1 mM	2.57 mL	12.87 mL	25.74 mL
5 mM	0.51 mL	2.57 mL	5.15 mL

*The above data is based on the productmolecular weight 388.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.