LY364947

Catalog No. A13446

LY364947是一种二杂芳基取代的吡唑类化合物，用作TGF-βRI（TGF-β受体I激酶）的选择性ATP竞争性抑制剂。

Technical details

Catalog Num	A13446
M. Wt	272.3
Formula	C17H12N4
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	396129-53-6
Synonyms	HTS 466284 ,TGF-β RI Kinase Inhibitor
SMILES	C1=CC=C2C(=C1)C(=CC=N2)C3=C(NN=C3)C4=CC=CC=N4

Biological Activity

LY364947是一种二杂芳基取代的吡唑类化合物，用作TGF-βRI（TGF-β受体I激酶）的选择性ATP竞争性抑制剂。

Targets

TGFβRI (Cell-free assay)	RIPK2 (Cell-free assay)	CK1δ (Cell-free assay)	TGFβRII (Cell-free assay)	MLK-7K (Cell-free assay)
59 nM	0.11 μM	0.22 μM	0.4 μM	1.4 μM

Solubility *

In vitro (25°C)	DMSO	1 mg/mL (3.67 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	4% DMSO+30% PEG 300+ddH2O	0.71 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	36.72 mL	183.62 mL	367.24 mL
0.5 mM	7.34 mL	36.72 mL	73.45 mL
1 mM	3.67 mL	18.36 mL	36.72 mL
5 mM	0.73 mL	3.67 mL	7.34 mL

*The above data is based on the productmolecular weight 272.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.