ZM 39923 HCl

Catalog No. A13509

ZM 39923 HCl是JAK3抑制剂（IC50 = 79 nM），其抑制表皮生长因子受体，JAK1和细胞周期蛋白依赖性激酶4（IC50s分别为2.4、40和10 M）的抑制作用较小。

Technical details

Catalog Num	A13509
M. Wt	367.9
Formula	C23H25NOHCl
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1021868-92-7
Synonyms	JAK3 Inhibitor IV
SMILES	O=C(CCN(CC1=CC=CC=C1)C(C)C)C2=CC3=CC=CC=C3C=C2.Cl

Biological Activity

ZM 39923 HCl是JAK3抑制剂（IC50 = 79 nM），其抑制表皮生长因子受体，JAK1和细胞周期蛋白依赖性激酶4（IC50s分别为2.4、40和10 M）的抑制作用较小。

Targets

TGM2	JAK3	EGFR	JAK1
10 nM	7.1(pIC50)	5.6(pIC50)	4.4(pIC50)

Solubility *

In vitro	DMSO	26 mg/mL (70.67 mM)
	Water	Insoluble
	Ethanol	7 mg/mL (19.02 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	27.18 mL	135.91 mL	271.81 mL
0.5 mM	5.44 mL	27.18 mL	54.36 mL
1 mM	2.72 mL	13.59 mL	27.18 mL
5 mM	0.54 mL	2.72 mL	5.44 mL

*The above data is based on the productmolecular weight 367.9. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.