Ro 31-8220 mesylate

Catalog No. A13514

Ro 31-8220 mesylate是一种PKC抑制剂,可抑制PKC激活剂佛波肉豆蔻酸酯乙酸酯(PMA,IC50 = 1.35 x 10(-6)M)或二酰基甘油(OAG,diC8)诱导的人PMN的刺激性液体胞吞作用
  • Dao-Lai Zhang, .et al. Gq activity- and β-arrestin-1 scaffolding-mediated ADGRG2/CFTR coupling are required for male fertility, eLife, 2018, 7: e33432 PMID: 29393851
Catalog Num A13514
M. Wt 553.7
Formula C25H23N5O2SCH3SO3H
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 138489-18-6
Synonyms BIM IX, Bisindolylmaleimide IX (mesylate)
SMILES CN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=CN(C5=CC=CC=C54)CCCSC(=N)N.CS(=O)(=O)O
Ro 31-8220 mesylate是一种PKC抑制剂,可抑制PKC激活剂佛波肉豆蔻酸酯乙酸酯(PMA,IC50 = 1.35 x 10(-6)M)或二酰基甘油(OAG,diC8)诱导的人PMN的刺激性液体胞吞作用
Targets
PKCα PKCβ2 PKCβ1 PKCε PKCγ
5 nM14 nM24 nM24 nM27 nM
In vitro DMSO 85 mg/mL (153.52 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.06 mL 90.3 mL 180.6 mL
0.5 mM 3.61 mL 18.06 mL 36.12 mL
1 mM 1.81 mL 9.03 mL 18.06 mL
5 mM 0.36 mL 1.81 mL 3.61 mL

*The above data is based on the productmolecular weight 553.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.