P276-00

Catalog No. A13547

P276-00是一种新型CDK1，CDK4和CDK9抑制剂，IC50分别为79 nM，63 nM和20 nM。在第2/3阶段。

Technical details

Catalog Num	A13547
M. Wt	438.3
Formula	C21H20ClNO5.HCl
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	920113-03-7
Synonyms	P276, P276-00
SMILES	CN1CC[C@H]([C@@H]1CO)C2=C(C=C(C3=C2OC(=CC3=O)C4=CC=CC=C4Cl)O)O.Cl

Biological Activity

P276-00是一种新型CDK1，CDK4和CDK9抑制剂，IC50分别为79 nM，63 nM和20 nM。在第2/3阶段。

Targets

Target	Value
CDK9/CyclinT1	IC50: 20nM
CDK4/CyclinD1	IC50: 63nM
CDK1/CyclinB	IC50: 79nM
CDK2/CyclinA	IC50: 224nM
CDK6/CyclinD3	IC50: 396nM
CDK2/CyclinE	IC50: 2.54μM
GSK-3β	IC50: 2.771μM
CDK7/CyclinH	IC50: 2.87μM
c-Src	IC50: <10μM
PKCα	IC50: 10μM
MAPK1	IC50: 22μM
PKC	IC50: 25μM
MAPK2	IC50: >100μM
PKA	IC50: 575μM

Solubility *

In vitro (25°C)	DMSO	79 mg/mL (180.24 mM)
	Water	79 mg/mL (180.24 mM)
	Ethanol	6 mg/mL (13.69 mM)
In vivo	30% propylene glycol, 5% Tween 80, 65% D5W	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.82 mL	114.08 mL	228.15 mL
0.5 mM	4.56 mL	22.82 mL	45.63 mL
1 mM	2.28 mL	11.41 mL	22.82 mL
5 mM	0.46 mL	2.28 mL	4.56 mL

*The above data is based on the productmolecular weight 438.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.