LEE011 (Ribociclib)

Catalog No. A13549

LEE011 (Ribociclib)是一种可口服的细胞周期蛋白依赖性激酶（CDK）抑制剂，靶向细胞周期蛋白D1/CDK4和细胞周期蛋白D3/CDK6细胞周期途径，具有潜在的抗肿瘤活性。

Technical details

Catalog Num	A13549
M. Wt	434.54
Formula	C23H30N8O
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1211441-98-3
Synonyms	LEE-011, LEE 011
SMILES	CN(C)C(=O)C1=CC2=CN=C(N=C2N1C3CCCC3)NC4=NC=C(C=C4)N5CCNCC5

Biological Activity

Targets

CDK4 (Cell-free assay)	CDK6 (Cell-free assay)

Solubility *

In vitro	DMSO	7 mg/mL (16.1 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	23.01 mL	115.06 mL	230.13 mL
0.5 mM	4.6 mL	23.01 mL	46.03 mL
1 mM	2.3 mL	11.51 mL	23.01 mL
5 mM	0.46 mL	2.3 mL	4.6 mL

*The above data is based on the productmolecular weight 434.54. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.