GSK2656157

Catalog No. A13577

GSK2656157是PERK酶活性的ATP竞争性抑制剂，IC50为0.9 nmol/L。对于PER（K）IC50值> 100 nmol/L，对300种激酶组合具有高度选择性。

Product Citations

Cao W, .et al. Hoxa5 alleviates obesity‐induced chronic inflammation by reducing ER stress and promoting M2 macrophage polarization in mouse adipose tissue, J Cell Mol Med, 2019, Aug 23 PMID: 31441588
Kosuke Ishikawa, .et al. A highly sensitive trap vector system for isolating reporter cells and identification of responsive genes, Biology Methods and Protocols, 2018, 1–10

Technical details

Catalog Num	A13577
M. Wt	416.45
Formula	C23H21FN6O
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1337532-29-2
Synonyms	GSK 2656157
SMILES	CC1=NC(=CC=C1)CC(=O)N2CCC3=C2C=CC(=C3F)C4=CN(C5=C4C(=NC=N5)N)C

Biological Activity

GSK2656157是PERK酶活性的ATP竞争性抑制剂，IC50为0.9 nmol/L。对于PER（K）IC50值> 100 nmol/L，对300种激酶组合具有高度选择性。

Targets

PERK (Cell-free assay)
0.9 nM

Solubility *

In vitro (25°C)	DMSO	28 mg/mL (67.23 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	1% CMC Na	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	24.01 mL	120.06 mL	240.12 mL
0.5 mM	4.8 mL	24.01 mL	48.02 mL
1 mM	2.4 mL	12.01 mL	24.01 mL
5 mM	0.48 mL	2.4 mL	4.8 mL

*The above data is based on the productmolecular weight 416.45. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.